Genetic Risk Assessment of Periodontal Disease in Healthy Patients

Forensic Research

FRANCESCO CARINCI ¹, ANNALISA PALMIERI ², AMBRA GIRARDI ², FRANCESCA CURA ², LUCA SCAPOLI ², DORINA LAURITANO ³

¹Chair of Maxillofacial Surgery, School of Medicine, University of Ferrara, Italy;
²Center of Molecular Genetics, CARISBO Foundation, and Institute of Histology and General Embryology, School of Medicine, University of Bologna, Italy;
³Department of traslational medicine and surgery, Neuroscience Centre of Milan, NeuroMi, University of Milan-Bicocca, Milan, Italy.

Abstract

Introduction: About 30% of the general population manifests periodontal disease (PD). Patients with parents with a compromised periodontal condition may need prosthetic or implantology treatment (PIT), therefore those
patients are at increased risk of developing PD during or after dental treatment. Hence the use of a genetic test for identify those most at risk of PD and submit them to very closely oral hygiene protocols, is mandatory. PIT of these patients must be done safely having previously assessed the risk of developing PD. Polymorphisms of IL6 and IL10 constitute risk factors for chronic periodontitis, so the use of a genetic test is fundamental to ensure a correct preventive protocol and plaque control in healthy patients.